This video is part one of six discussing the importance of MRI technology and its application to traumatic brain injury. It begins with the history of brain imaging techniques ranging from CT scanning to modern MRI scanning. Basic aspects of NeuroQuant®, an FDA approved software program for measuring brain MRI volume in human subjects, are discussed. The video examines patient case examples using NeuroQuant® Standard, NeuroQuant® Extended and the NeuroQuant® longitudinal design.