MRI brain volume analysis using NeuroQuant^® software

Case example 1: A 57 year old patient suffered a mild-to-moderate traumatic brain injury. He had multiple persistent neuropsychiatric sequelae, including impaired short-term memory. The MRI was interpreted in the traditional way (by visual inspection of images) as showing no atrophy. NeuroQuant^® analysis was performed. The NeuroQuant^® standard report showed severe atrophy of the hippocampi.  (click here to read publication)

Case example 2: A 42 year old patient suffered a mild traumatic brain injury.  He had multiple neuropsychiatric symptoms which persisted for a few years after the injury. Initial CT scans and MRI scans of the brain showed no signs of atrophy. Brain volume was measured using NeuroQuant®.  Volumetric cross-sectional (one point in time) analysis also showed no atrophy. However, volumetric longitudinal (two points in time) analysis showed progressive atrophy in several brain regions. This case illustrated in a single patient the principle discovered in multiple previous group studies, namely that the longitudinal design is more powerful than the cross-sectional design for finding atrophy in patients with traumatic brain injury.  (click here to read publication)
Example of NeuroQuant® reports and video for this case report (However, volumetric longitudinal (two points in time) analysis showed progressive atrophy in several brain regions.)