MRI brain volume analysis using NeuroQuant software
NeuroQuant is an exciting development for uncovering evidence of brain injury in our patients with mild to moderate traumatic brain injury. Most patients with mild to moderate traumatic brain injury (TBI) have normal CT scans and MRI scans. For years, advances in structural brain imaging have promised to remedy this situation. Finally, the promises of the research laboratory are readily available for everyday patients in the clinic.
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NeuroQuant is a software program approved by the FDA for measuring brain MRI volume
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NeuroQuant automatically identifies several MRI brain regions and measures the volume of each. These data are then compared to MRI data from normal control subjects. In addition to the NeuroQuant standard report (which measures 11 brain regions but compares only 3 regions to normal controls) we have extended the utility of the test by identifying 15 brain regions, comparing all 15 to normal controls, and examining longitudinal change (obtaining 2 MRIs in the same patient, several months apart, and looking for progressive atrophy). Example NeuroQuant extended report.
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Dr. Ross and colleagues have had scientific abstracts accepted for presentation at national meetings (see Dr. Ross’s CV).
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Important: For mold patients considering a NeuroQuant analysis, please follow the instructions under “Clinical Services-Mold Exposure” before contacting VIN.
Case Studies
Case Example 1:
A 57 year old patient suffered a mild-to-moderate traumatic brain injury. He had multiple persistent neuropsychiatric sequelae, including impaired short-term memory. The MRI was interpreted in the traditional way (by visual inspection of images) as showing no atrophy. NeuroQuant analysis was performed. The NeuroQuant standard report showed severe atrophy of the hippocampi.
(click here to read publication)
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Case Example 2:
A 42 year old patient suffered a mild traumatic brain injury. He had multiple neuropsychiatric symptoms which persisted for a few years after the injury. Initial CT scans and MRI scans of the brain showed no signs of atrophy. Brain volume was measured using NeuroQuant. Volumetric cross-sectional (one point in time) analysis also showed no atrophy. However, volumetric longitudinal (two points in time) analysis showed progressive atrophy in several brain regions. This case illustrated in a single patient the principle discovered in multiple previous group studies, namely that the longitudinal design is more powerful than the cross-sectional design for finding atrophy in patients with traumatic brain injury. (click here to read publication)
Example of NeuroQuant reports and video for this case report
(However, volumetric longitudinal (two points in time) analysis showed progressive atrophy in several brain regions.)